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KMID : 0545120110210030263
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Journal of Microbiology and Biotechnology
2011 Volume.21 No. 3 p.263 ~ p.266
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Antiviral Activity of Methylelaiophylin, an α-Glucosidase InhibitorAntiviral Activity of Methylelaiophylin, an α-Glucosidase Inhibitor
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Lee Do-seung
Woo Jin-Kyu
Kim Dong-Hern
Kim Min-Young
Somi K. Cho
Kim Jae-Hoon
Park Se-Pill
Lee Hyo-Yeon
Riu Key-Zung
Lee Dong-Sun
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Abstract
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Methylelaiophylin isolated from Streptomyces melanosporofaciens was selected as an α-glucosidase inhibitor with an IC50 value of 10 μM. It showed mixedtype inhibition of α-glucosidase with a Ki value of 5.94 μM. In addition, methylelaiophylin inhibited the intracellular trafficking of hemagglutinin-neuramidase (HN), a glycoprotein of Newcastle disease virus (NDV), in baby hamster kidney (BHK) cells. Methylelaiophylin inhibited the cell surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis in NDV-infected BHK cells.
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KEYWORD
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α-glucosidase inhibitor, methylelaiophylin, trafficking inhibitor
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